GTP- and GDP-Dependent Rab27a Effectors in Pancreatic Beta-Cells
نویسندگان
چکیده
منابع مشابه
Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells.
The small GTPase Rab27a, along with the isoforms of Rab3, is present on insulin secretory granules and has been implicated in regulation of Ca(2+)-triggered exocytosis. We have used membrane capacitance measurements to define the role of Rab27a in regulating the size and refilling of distinct pools of insulin granules by comparison of evoked secretory responses from Rab27a-null ashen and strain...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2015
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00886